Professor
Salvatore Sauro, University CEU Cardenal Herrera, Spain, along with
international researchers from Finland, Brazil, USA and U.K, demonstrated the
efficacy of Zoledronic acid along with bio-active ion-releasing resin-based
dental adhesives in reducing the occurrence of caries.
This combination effectively
reduces the degradation of dentin collagen and promotes remineralisation at
resin-dentin interface.
The Agent......Zoledronic acid is a bisphosphonate commonly used in
the treatment of osteoporosis, Paget’s disease and bone cancer. It slows bone
breakdown, increases bone density and reduces the amount of calcium released
into the blood.
Action.......Salvatore Sauro in his research showed that Zoledronic acid had
the potential to inhibit the action of dentin MMP’s (Matrix Metalloproteinase)
to hydrolyze the organic matrix of demineralized dentin, thus improving the
bondage of resins to dentin and decreasing the incidence of caries.
Dentin MMP’s
are proteolytic enzymes trapped within the mineralized dentin matrix that are
activated following acid-etching. It targets the collagen fibres that are left
exposed after bonding with resin due to imperfect resin impregnation of the
demineralized dentin matrix.
Thus, this combination is definitely magical!
Thus, this combination is definitely magical!
 |
| Wohooo! I need not worry .....My pearly whites are rescued! |
Certainly,
one can say that this premier research has paved the way for a new dental
adhesive in town!
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